AUTOCAL Simulation Fails – “Number of failed simulations too high”

Hello everyone,

I'm currently working on a hydrological model in MIKE SHE, and I'm running into an issue during a sensitivity analysis with AUTOCAL.

Each time I launch the simulation, I get the following error after a few parameter sets: 
UTOCAL simulation: Sensitivity analysis

Simulation option:  Sensitivity analysis
Algorithm:          Local sensitivity analysis

Evaluation of parameter set No. 1 initiated
Evaluation of parameter set No. 2 initiated
Evaluation of parameter set No. 3 initiated
Evaluation of parameter set No. 4 initiated
Evaluation of parameter set No. 5 initiated
Evaluation of parameter set No. 6 initiated
Evaluation of parameter set No. 7 initiated
Evaluation of parameter set No. 8 initiated
Evaluation of parameter set No. 3 completed: FAILED - model run error
Evaluation of parameter set No. 9 initiated
Evaluation of parameter set No. 4 completed: FAILED - model run error
 
Error: Unable to continue. No of failed simulations too high.
 

Has anyone experienced this before?
Thanks in advance for your help!